Ubrogepant (Ubrelvy®): A Tablet to Stop Migraine Attacks

Looking for a detailed medication handout of Ubrelvy®? Explore our downloadable handouts created by the specialists at the Ottawa Headache Centre.

Ubrogepant (Ubrelvy®) is used for the acute treatment migraine attacks. It is an oral tablet taken daily as needed after a migraine attack starts, and the dose can be repeated once 2 hours later.

At the Ottawa Headache Centre, we consider ubrogepant (Ubrelvy®) when:

• there is a high frequency of migraine attacks risking medication-overuse headache

• the side-effects of triptans are poorly tolerated

• triptans have not been effective in stopping migraine attacks

• there are contraindications to using triptans (e.g., high risk of stroke or heart attack)

• there is concurrent medication-overuse headache

• multiple different acute treatments are needed

• patients need better control of menstrual-related migraine

Coverage of ubrogepant (Ubrelvy®) in Ontario

Currently, ubrogepant (Ubrelvy®) does not have coverage under the Exceptional Access Program.

Individual drug plans vary regarding their coverage of gepants for migraine.

Next steps to get started on ubrogepant (Ubrelvy®) in Ottawa

If you are having poorly controlled migraine attacks, then ask for a referral to the Ottawa Headache Centre. We can explore whether gepants can play a role in the acute treatment of your attacks.

Ubrogepant (Ubrelvy®) is an oral tablet (i.e., by mouth) that is used daily as needed after a migraine attack starts. A dose can be repeated 2 hours later if still needed.

It blocks the action of CGRP, a chemical involved in migraine pain signaling.

By reducing CGRP activity, it:

What are the benefits of using ubrogepant (Ubrelvy®) to treat migraine attacks?

As a gepant, the benefits of ubrogepant (Ubrelvy®) include that it:

• does not cause medication overuse headache

• does not constrict blood vessels

• is generally very tolerable for most people

• is safe for many people who cannot take triptans

Next steps

Ubrogepant (Ubrelvy®) can be a useful medication to stop migraine attacks. 

If you are considering Ubrelvy® (or have been referred), our consultation helps:

• confirm whether ubrogepant (Ubrelvy®) fits your migraine profile

• understand the benefits and short-comings of gepants, especially when compared to other acute medications (i.e., triptans)

• and place it into a broader, individualized care plan (including acute and non-medication strategies).

Ask your doctor for a referral to the Ottawa Headache Centre if you want to learn more about your migraine-specific preventive options.

Disclaimer

This material is provided for educational purposes and does not replace independent clinical judgment or institutional protocols. Management decisions remain the responsibility of the treating clinician.